InQuanto Integrates NVIDIA cuQuantum for Native GPU Support and Prepares for the Era of Quantum Supercomputing

November 21, 2024

Chemistry plays a central role in the modern global economy, as it has for centuries. From Antoine Lavoisier to Alessandro Volta, Marie Curie to Venkatraman Ramakrishnan, pioneering chemists drove progress in fields such as combustion, electrochemistry, and biochemistry. They contributed to our mastery of critical 21st century materials such as biodegradable plastics, semiconductors, and life-saving pharmaceuticals.

Advances in high-performance computing (HPC) and AI have brought fundamental and industrial science ever more within the scope of methods like data science and predictive analysis. In modern chemistry, it has become routine for research to be aided by computational models run in silico. Yet, due to their intrinsically quantum mechanical nature, “strongly correlated” chemical systems – those involving strongly interacting electrons or highly interdependent molecular behaviors – prove extremely hard to accurately simulate using classical computers alone. Quantum computers running quantum algorithms are designed to meet this need. Strongly correlated systems turn up in potential applications such as smart materials, high-temperature superconductors, next-generation electronic devices, batteries and fuel cells, revealing the economic potential of extending our understanding of these systems, and the motivation to apply quantum computing to computational chemistry.

For senior business and research leaders driving value creation and scientific discovery, a critical question is how will the introduction of quantum computers affect the trajectory of computational approaches to fundamental and industrial science?

Introducing InQuanto v4.0

This is the exciting context for our announcement of InQuanto v4.0, the latest iteration of our computational chemistry platform for quantum computers. Developed over many years in close partnership with computational chemists and materials scientists, InQuanto has become an essential tool for teams using the most advanced methods for simulating molecular and material systems. InQuanto v4.0 is packed with powerful updates, including the capability to incorporate NVIDIA’s tensor network methods for large-scale classical simulations supported by graphical processing units (GPUs).

When researching chemistry on quantum computers, we use classical HPC to perform tasks such as benchmarking, and for classical pre- and post-processing with computational chemistry methods such as density functional theory. This powerful hybrid quantum-classical combination with InQuanto accelerated our work with partners such as , and . Global businesses and national governments alike are gearing up for the use of such hybrid “quantum supercomputers” to become standard practice.

In a recent technical blog post, we explored the rapid development and deployment of InQuanto for research and enterprise users, offering insights for combining quantum and high-performance classical methods with only a few lines of code. Here, we provide a higher-level overview of the value InQuanto brings to fundamental and industrial research teams.

InQuanto v4.0 – under the hood

InQuanto v4.0 is the most powerful version to date of our advanced quantum computational chemistry platform. It supports our users in applying quantum and classical computing methods to problems in chemistry and, increasingly, adjacent fields such as condensed matter physics.

Like previous versions of InQuanto, this one offers state-of-the-art algorithms, methods, and error handling techniques out of the box. Quantum error correction and detection have enabled rapid progress in quantum computing, such as groundbreaking demonstrations in partnership with Microsoft, in April and September 2024, of highly reliable “logical qubits”. Qubits are the core information-carrying components of a quantum computer and by forming them into an ensemble, they are more resistant to errors, allowing more complex problems to be tackled while producing accurate results. InQuanto continues to offer leading-edge quantum error detection protocols as standard and supports users to explore the potential of algorithms for fault-tolerant machines.

InQuanto v4.0 also marks the significant step of introducing native support for tensor networks using GPUs to accelerate simulations. In 2022, and NVIDIA teamed up on one of the quantum computing industry’s earliest quantum-classical collaborations. InQuanto v4.0 introduces classical tensor network methods via an interface with NVIDIA's cuQuantum SDK. Interfacing with cuQuantum enables the simulation of many quantum circuits via the use of GPUs for applications in chemistry that were previously inaccessible, particularly those with larger numbers of qubits.

“Hybrid quantum-classical supercomputing is accelerating quantum computational chemistry research. With ’s InQuanto v4.0 platform and NVIDIA’s cuQuantum SDK, InQuanto users now have access to unique tensor-network-based methods, enabling large-scale and high-precision quantum chemistry simulations” - Tim Costa, Senior Director of HPC and Quantum Computing at NVIDIA

We are also responding to our users’ needs for more robust, enterprise-grade management of applications and data, by incorporating InQuanto into Nexus. This integration makes it far easier and more efficient to build hybrid workflows, decode and store data, and use powerful analytical methods to accelerate scientific and technical progress in critical fields in natural science.

Adding further capabilities, we our integration of InQuanto with Microsoft’s Azure Quantum Elements (AQE), allowing users to seamlessly combine AQE’s state-of-the-art HPC and AI methods with the enhanced quantum capabilities of InQuanto in a single workflow. The first end-to-end workflow using HPC, AI and quantum computing was demonstrated using AQE and Systems hardware, achieving chemical accuracy and demonstrating the advantage of logical qubits compared to physical qubits in modeling a catalytic reaction.

Where InQuanto takes us next

In the coming years, we expect to see scientific and economic progress using the powerful combination of quantum computing, HPC, and artificial intelligence. Each of these computing paradigms contributes to our ability to solve important problems. Together, their combined impact is far greater than the sum of their parts, and we recognize that these have the potential to drive valuable computational innovation in industrial use-cases that really matter, such as in energy generation, transmission and storage, and in chemical processes essential to agriculture, transport, and medicine.

Building on our recent hardware roadmap announcement, which supports scientific quantum advantage and a commercial tipping point in 2029, we are demonstrating the value of owning and building out the full quantum computing stack with a unified goal of accelerating quantum computing, integrating with HPC and AI resources where it shows promise, and using the power of the “quantum supercomputer” to make a positive difference in fundamental and industrial chemistry and related domains.

In close collaboration with our customers, we are driving towards systems capable of supporting quantum advantage and unlocking tangible and significant business value.

To access InQuanto today, including Systems and third-party hardware and emulators, visit: /products-solutions/inquanto

To get started with Nexus, which meets all your quantum computing needs across Systems and third-party backends, visit: /products-solutions/nexus

To find out more and access Systems, visit: /products-solutions/quantinuum-systems

About

,the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. ’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, leads the quantum computing revolution across continents.

Blog
October 30, 2025
Scalable Quantum Error Detection

Typically, Quantum Error Detection (QED) is viewed as a short-term solution—a non-scalable, stop-gap until full fault tolerance is achieved at scale.

That’s just changed, thanks to a serendipitous discovery made by our team. Now, QED can be used in a much wider context than previously thought. Our team made this discovery while studying the contact process, which describes things like how diseases spread or how water permeates porous materials. In particular, our team was studying the quantum contact process (QCP), a problem they had tackled before, which helps physicists understand things like phase transitions. In the process (pun intended), they came across what senior advanced physicist, Eli Chertkov, described as “a surprising result.”

While examining the problem, the team realized that they could convert detected errors due to noisy hardware into random resets, a key part of the QCP, thus avoiding the exponentially costly overhead of post-selection normally expected in QED.

To understand this better, the team developed a new protocol in which the encoded, or logical, quantum circuit adapts to the noise generated by the quantum computer. They quickly realized that this method could be used to explore other classes of random circuits similar to the ones they were already studying.

The team put it all together on System Model H2 to run a complex simulation, and were surprised to find that they were able to achieve near break-even results, where the logically encoded circuit performed as well as its physical analog, thanks to their clever application of QED. Ultimately, this new protocol will allow QED codes to be used in a scalable way, saving considerable computational resources compared to full quantum error correction (QEC).

Researchers at the crossroads of quantum information, quantum simulation, and many-body physics will take interest in this protocol and use it as a springboard for inventing new use cases for QED.

Stay tuned for more, our team always has new tricks up their sleeves.

Learn mode about System Model H2 with this video:

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Blog
October 23, 2025
Mapping the Hunt for Quantum Advantage

By Konstantinos Meichanetzidis

When will quantum computers outperform classical ones?

This question has hovered over the field for decades, shaping billion-dollar investments and driving scientific debate.

The question has more meaning in context, as the answer depends on the problem at hand. We already have estimates of the quantum computing resources needed for Shor’s algorithm, which has a superpolynomial advantage for integer factoring over the best-known classical methods, threatening cryptographic protocols. Quantum simulation allows one to glean insights into exotic materials and chemical processes that classical machines struggle to capture, especially when strong correlations are present. But even within these examples, estimates change surprisingly often, carving years off expected timelines. And outside these famous cases, the map to quantum advantage is surprisingly hazy.

Researchers at have taken a fresh step toward drawing this map. In a new theoretical framework, Harry Buhrman, Niklas Galke, and Konstantinos Meichanetzidis introduce the concept of “queasy instances” (quantum easy) – problem instances that are comparatively easy for quantum computers but appear difficult for classical ones.

From Problem Classes to Problem Instances

Traditionally, computer scientists classify problems according to their worst-case difficulty. Consider the problem of Boolean satisfiability, or SAT, where one is given a set of variables (each can be assigned a 0 or a 1) and a set of constraints and must decide whether there exists a variable assignment that satisfies all the constraints. SAT is a canonical NP-complete problem, and so in the worst case, both classical and quantum algorithms are expected to perform badly, which means that the runtime scales exponentially with the number of variables. On the other hand, factoring is believed to be easier for quantum computers than for classical ones. But real-world computing doesn’t deal only in worst cases. Some instances of SAT are trivial; others are nightmares. The same is true for optimization problems in finance, chemistry, or logistics. What if quantum computers have an advantage not across all instances, but only for specific “pockets” of hard instances? This could be very valuable, but worst-case analysis is oblivious to this and declares that there is no quantum advantage.

To make that idea precise, the researchers turned to a tool from theoretical computer science: Kolmogorov complexity. This is a way of measuring how “regular” a string of bits is, based on the length of the shortest program that generates it. A simple string like 0000000000 can be described by a tiny program (“print ten zeros”), while the description of a program that generates a random string exhibiting no pattern is as long as the string itself. From there, the notion of instance complexity was developed: instead of asking “how hard is it to describe this string?”, we ask “how hard is it to solve this particular problem instance (represented by a string)?” For a given SAT formula, for example, its polynomial-time instance complexity is the size of the smallest program that runs in polynomial time and decides whether the formula is satisfiable. This smallest program must be consistently answering all other instances, and it is also allowed to declare “I don’t know”.

In their new work, the team extends this idea into the quantum realm by defining polynomial-time quantum instance complexity as the size of the shortest quantum program that solves a given instance and runs on polynomial time. This makes it possible to directly compare quantum and classical effort, in terms of program description length, on the very same problem instance. If the quantum description is significantly shorter than the classical one, that problem instance is one the researchers call “qܱ𲹲”: quantum-easy and classically hard. These queasy instances are the precise places where quantum computers offer a provable advantage – and one that may be overlooked under a worst-case analysis.

Why “Queasy”?

The playful name captures the imbalance between classical and quantum effort. A queasy instance is one that makes classical algorithms struggle, i.e. their shortest descriptions of efficient programs that decide them are long and unwieldy, while a quantum computer can handle the same instance with a much simpler, faster, and shorter program. In other words, these instances make classical computers “queasy,” while quantum ones solve them efficiently and finding them quantum-easy. The key point of these definitions lies in demonstrating that they yield reasonable results for well-known optimisation problems.

By carefully analysing a mapping from the problem of integer factoring to SAT (which is possible because factoring is inside NP and SAT is NP-complete) the researchers prove that there exist infinitely many queasy SAT instances. SAT is one of the most central and well-studied problems in computer science that finds numerous applications in the real-world. The significant realisation that this theoretical framework highlights is that SAT is not expected to yield a blanket quantum advantage, but within it lie islands of queasiness – special cases where quantum algorithms decisively win.

Algorithmic Utility

Finding a queasy instance is exciting in itself, but there is more to this story. Surprisingly, within the new framework it is demonstrated that when a quantum algorithm solves a queasy instance, it does much more than solve that single case. Because the program that solves it is so compact, the same program can provably solve an exponentially large set of other instances, as well. Interestingly, the size of this set depends exponentially on the queasiness of the instance!

Think of it like discovering a special shortcut through a maze. Once you’ve found the trick, it doesn’t just solve that one path, but reveals a pattern that helps you solve many other similarly built mazes, too (even if not optimally). This property is called algorithmic utility, and it means that queasy instances are not isolated curiosities. Each one can open a doorway to a whole corridor with other doors, behind which quantum advantage might lie.

A North Star for the Field

Queasy instances are more than a mathematical curiosity; this is a new framework that provides a language for quantum advantage. Even though the quantities defined in the paper are theoretical, involving Turing machines and viewing programs as abstract bitstrings, they can be approximated in practice by taking an experimental and engineering approach. This work serves as a foundation for pursuing quantum advantage by targeting problem instances and proving that in principle this can be a fruitful endeavour.

The researchers see a parallel with the rise of machine learning. The idea of neural networks existed for decades along with small scale analogue and digital implementations, but only when GPUs enabled large-scale trial and error did they explode into practical use. Quantum computing, they suggest, is on the cusp of its own heuristic era. ‾ܰپ” will be prominent in finding queasy instances, which have the right structure so that classical methods struggle but quantum algorithms can exploit, to eventually arrive at solutions to typical real-world problems. After all, quantum computing is well-suited for small-data big-compute problems, and our framework employs the concepts to quantify that; instance complexity captures both their size and the amount of compute required to solve them.

Most importantly, queasy instances shift the conversation. Instead of asking the broad question of when quantum computers will surpass classical ones, we can now rigorously ask where they do. The queasy framework provides a language and a compass for navigating the rugged and jagged computational landscape, pointing researchers, engineers, and industries toward quantum advantage.

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Blog
September 15, 2025
Quantum World Congress 2025

From September 16th – 18th, (QWC) brought together visionaries, policymakers, researchers, investors, and students from across the globe to discuss the future of quantum computing in Tysons, Virginia.

is forging the path to universal, fully fault-tolerant quantum computing with our integrated full-stack. With our quantum experts were on site, we showcased the latest on Systems, the world’s highest-performing, commercially available quantum computers, our new software stack featuring the key additions of Guppy and Selene, our path to error correction, and more.

Highlights from QWC

Dr. Patty Lee Named the Industry Pioneer in Quantum

The Quantum Leadership Awards celebrate visionaries transforming quantum science into global impact. This year at QWC, Dr. Patty Lee, our Chief Scientist for Hardware Technology Development, was named the Industry Pioneer in Quantum! This honor celebrates her more than two decades of leadership in quantum computing and her pivotal role advancing the world’s leading trapped-ion systems. .

Keynote with 's CEO,Dr. RajeebHazra

At QWC 2024, ’s President & CEO, Dr. Rajeeb “Raj” Hazra, took the stage to showcase our commitment to advancing quantum technologies through the unveiling of our roadmap to universal, fully fault-tolerant quantum computing by the end of this decade. This year at QWC 2025, Raj shared the progress we’ve made over the last year in advancing quantum computing on both commercial and technical fronts and exciting insights on what’s to come from . .

Panel Session:Policy Priorities for Responsible Quantum and AI

As part of the Track Sessions on Government & Security, ’s Director of Government Relations, Ryan McKenney, discussed “Policy Priorities for Responsible Quantum and AI” with Jim Cook from Actions to Impact Strategies and Paul Stimers from Quantum Industry Coalition.

Fireside Chat:Establishing a Pro-Innovation Regulatory Framework

During the Track Session on Industry Advancement, ’s Chief Legal Officer, Kaniah Konkoly-Thege,and Director of Government Relations, Ryan McKenney, discussed the importance of “Establishing a Pro-Innovation Regulatory Framework”.

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